Explore the fascinating simulation of metabolic zonation and its pivotal role in regulating hepatic function in both health and disease, including Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Using an innovative continuum biomechanical model, we've simulated the complex interplay between microperfusion, oxygen gradients, and fat metabolism in liver lobules. Our tri-phasic, bi-scale approach offers a comprehensive understanding of zonated fat accumulation, paving the way for deeper insights into liver health. By bridging scales and integrating biological parameters, our model predicts fat distribution patterns-whether periportal or pericentral-based on initial and boundary conditions.
Lambers, L., Waschinsky, N., Schleicher, J. et al. Quantifying fat zonation in liver lobules: an integrated multiscale in silico model combining disturbed microperfusion and fat metabolism via a continuum biomechanical bi-scale, tri-phasic approach. Biomech Model Mechanobiol (2024).
